Design and development of polymers for gene delivery
Identifieur interne : 001E82 ( Main/Exploration ); précédent : 001E81; suivant : 001E83Design and development of polymers for gene delivery
Auteurs : Daniel W. Pack [États-Unis] ; Allan S. Hoffman [États-Unis] ; Suzie Pun [États-Unis] ; Patrick S. Stayton [États-Unis]Source :
- Nature Reviews Drug Discovery [ 1474-1776 ] ; 2005-07.
Abstract
The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure–function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.
Url:
DOI: 10.1038/nrd1775
Affiliations:
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Pack</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, University of Illinois, Box C-3, 600 South Mathews Avenue, Urbana, Illinois 61801</wicri:regionArea><wicri:noRegion>Illinois 61801</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author><author><name sortKey="Hoffman, Allan S" sort="Hoffman, Allan S" uniqKey="Hoffman A" first="Allan S." last="Hoffman">Allan S. 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Stayton</name><affiliation wicri:level="4"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of Washington, Box 352255, Seattle, Washington 98195</wicri:regionArea><orgName type="university">Université de Washington</orgName><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Nature Reviews Drug Discovery</title><idno type="ISSN">1474-1776</idno><idno type="eISSN">1474-1784</idno><imprint><publisher>Nature Publishing Group</publisher><date when="2005-07">2005-07</date><biblScope unit="vol">4</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="581">581</biblScope><biblScope unit="page" to="593">593</biblScope><date type="Copyright" when="2005">2005</date></imprint><idno type="ISSN">1474-1776</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1474-1776</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="eng">The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure–function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Pack, Daniel W" sort="Pack, Daniel W" uniqKey="Pack D" first="Daniel W." last="Pack">Daniel W. Pack</name></noRegion><name sortKey="Hoffman, Allan S" sort="Hoffman, Allan S" uniqKey="Hoffman A" first="Allan S." last="Hoffman">Allan S. Hoffman</name><name sortKey="Pack, Daniel W" sort="Pack, Daniel W" uniqKey="Pack D" first="Daniel W." last="Pack">Daniel W. Pack</name><name sortKey="Pun, Suzie" sort="Pun, Suzie" uniqKey="Pun S" first="Suzie" last="Pun">Suzie Pun</name><name sortKey="Stayton, Patrick S" sort="Stayton, Patrick S" uniqKey="Stayton P" first="Patrick S." last="Stayton">Patrick S. Stayton</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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